Edexcel CP2 2023 June — Question 9 14 marks

Exam BoardEdexcel
ModuleCP2 (Core Pure 2)
Year2023
SessionJune
Marks14
PaperDownload PDF ↗
Mark schemeDownload PDF ↗
TopicSystems of differential equations
TypeComplex roots giving oscillatory solution
DifficultyChallenging +1.2 This is a structured multi-part question on coupled differential equations with a modeling context. Part (a) is routine algebraic manipulation (differentiate and substitute), part (b) requires solving a standard second-order DE with constant coefficients, part (c) applies initial conditions, and part (d) interprets the steady-state. While it involves several steps and techniques, each part follows standard procedures taught in Core Pure 2 with clear signposting. The coefficients are messy but the mathematical pathway is straightforward, making this moderately above average difficulty but not requiring novel insight.
Spec4.10e Second order non-homogeneous: complementary + particular integral4.10h Coupled systems: simultaneous first order DEs

  1. A patient is treated by administering an antibiotic intravenously at a constant rate for some time.
Initially there is none of the antibiotic in the patient.
At time \(t\) minutes after treatment began
  • the concentration of the antibiotic in the blood of the patient is \(x \mathrm { mg } / \mathrm { ml }\)
  • the concentration of the antibiotic in the tissue of the patient is \(y \mathrm { mg } / \mathrm { ml }\)
The concentration of antibiotic in the patient is modelled by the equations $$\begin{aligned} & \frac { \mathrm { d } x } { \mathrm {~d} t } = 0.025 y - 0.045 x + 2 \\ & \frac { \mathrm {~d} y } { \mathrm {~d} t } = 0.032 x - 0.025 y \end{aligned}$$
  1. Show that $$40000 \frac { \mathrm {~d} ^ { 2 } y } { \mathrm {~d} t ^ { 2 } } + 2800 \frac { \mathrm {~d} y } { \mathrm {~d} t } + 13 y = 2560$$
  2. Determine, according to the model, a general solution for the concentration of the antibiotic in the patient's tissue at time \(t\) minutes after treatment began.
  3. Hence determine a particular solution for the concentration of the antibiotic in the tissue at time \(t\) minutes after treatment began. To be effective for the patient the concentration of antibiotic in the tissue must eventually reach a level between \(185 \mathrm { mg } / \mathrm { ml }\) and \(200 \mathrm { mg } / \mathrm { ml }\).
  4. Determine whether the rate of administration of the antibiotic is effective for the patient, giving a reason for your answer.

Question 9:
Part (a):
AnswerMarks Guidance
Answer/WorkingMark Guidance
\(\frac{d^2y}{dt^2} = 0.032\frac{dx}{dt} - 0.025\frac{dy}{dt}\) and \(\frac{dx}{dt} = \frac{1}{0.032}\left(0.025\frac{dy}{dt} + \frac{d^2y}{dt^2}\right)\)B1 Differentiates the second equation with respect to \(t\) correctly. May have rearranged to make \(x\) the subject first. Dot notation allowed.
Substitutes for \(x\): \(\frac{d^2y}{dt^2} = 0.0008y - \frac{0.00144}{0.032}\left(\frac{dy}{dt} + 0.025y\right) + 0.064 - 0.025\frac{dy}{dt}\)M1 Uses the second equation to eliminate \(x\) to achieve an equation in \(y\), \(\frac{dy}{dt}\), \(\frac{d^2y}{dt^2}\)
\(40000\frac{d^2y}{dt^2} + 2800\frac{dy}{dt} + 13y = 2560\)A1\* Achieves the printed answer with no errors. Allow dot notation.
Part (b):
AnswerMarks Guidance
Answer/WorkingMark Guidance
\(40000m^2 + 2800m + 13 = 0 \Rightarrow m = \ldots\)M1 Uses the model to form and attempt to solve the auxiliary equation
CF: \(y = Ae^{m_1 t} + Be^{m_2 t}\)M1 Forms the complementary function correct for their roots. Must be in terms of \(t\) only (not \(x\))
CF: \(y = Ae^{\frac{-t}{200}} + Be^{\frac{-13t}{200}}\)A1 Correct CF
PI: Try \(y = k \Rightarrow 13k = 2560 \Rightarrow k = \frac{2560}{13}\)M1 Chooses correct form of PI and uses complete method to find PI
GS: \(y = Ae^{-0.005t} + Be^{-0.065t} + \frac{2560}{13}\)A1ft Combines CF with correct PI. Accept awrt 197
Part (c):
AnswerMarks Guidance
Answer/WorkingMark Guidance
\(t=0, y=0 \Rightarrow 0 = A + B + \frac{2560}{13}\)M1 Uses initial conditions to set up equation in \(A\) and \(B\)
\(t=0, y=0, x=0 \Rightarrow \frac{dy}{dt} = 0.032\times0 - 0.025\times0 = 0\)B1 Uses initial conditions to find value of \(\frac{dy}{dt}\) when \(t=0\). Can be implied.
\(\frac{dy}{dt} = -\frac{A}{200}e^{\frac{-t}{200}} - \frac{13B}{200}e^{\frac{-13t}{200}} = 0 \Rightarrow -\frac{A}{200} - \frac{13B}{200} = 0 \Rightarrow A = -13B\)M1 Differentiates GS, substitutes \(t=0\) and sets equal to initial value of \(\frac{dy}{dt}\) to form another equation in \(A\) and \(B\)
\(y = -\frac{640}{3}e^{\frac{-t}{200}} + \frac{640}{39}e^{\frac{-13t}{200}} + \frac{2560}{13}\)A1 Correct particular solution, accepting awrt 197
Part (d):
AnswerMarks Guidance
Answer/WorkingMark Guidance
As \(t \to \infty\), \(e^{-kt} \to 0\) for \(k > 0\) so \(y \to \ldots\)M1 Uses the limit of the exponential terms being zero to find the long term limit of the concentration
\(y \to \frac{2560}{13} \approx 196\) or \(197\), so the rate of administration is sufficient to reach the required level.A1ft Follow through on their constant term and draws a relevant conclusion
## Question 9:

### Part (a):

| Answer/Working | Mark | Guidance |
|---|---|---|
| $\frac{d^2y}{dt^2} = 0.032\frac{dx}{dt} - 0.025\frac{dy}{dt}$ and $\frac{dx}{dt} = \frac{1}{0.032}\left(0.025\frac{dy}{dt} + \frac{d^2y}{dt^2}\right)$ | **B1** | Differentiates the second equation with respect to $t$ correctly. May have rearranged to make $x$ the subject first. Dot notation allowed. |
| Substitutes for $x$: $\frac{d^2y}{dt^2} = 0.0008y - \frac{0.00144}{0.032}\left(\frac{dy}{dt} + 0.025y\right) + 0.064 - 0.025\frac{dy}{dt}$ | **M1** | Uses the second equation to eliminate $x$ to achieve an equation in $y$, $\frac{dy}{dt}$, $\frac{d^2y}{dt^2}$ |
| $40000\frac{d^2y}{dt^2} + 2800\frac{dy}{dt} + 13y = 2560$ | **A1\*** | Achieves the printed answer with no errors. Allow dot notation. |

### Part (b):

| Answer/Working | Mark | Guidance |
|---|---|---|
| $40000m^2 + 2800m + 13 = 0 \Rightarrow m = \ldots$ | **M1** | Uses the model to form and attempt to solve the auxiliary equation |
| CF: $y = Ae^{m_1 t} + Be^{m_2 t}$ | **M1** | Forms the complementary function correct for their roots. Must be in terms of $t$ only (not $x$) |
| CF: $y = Ae^{\frac{-t}{200}} + Be^{\frac{-13t}{200}}$ | **A1** | Correct CF |
| PI: Try $y = k \Rightarrow 13k = 2560 \Rightarrow k = \frac{2560}{13}$ | **M1** | Chooses correct form of PI and uses complete method to find PI |
| GS: $y = Ae^{-0.005t} + Be^{-0.065t} + \frac{2560}{13}$ | **A1ft** | Combines CF with correct PI. Accept awrt 197 |

### Part (c):

| Answer/Working | Mark | Guidance |
|---|---|---|
| $t=0, y=0 \Rightarrow 0 = A + B + \frac{2560}{13}$ | **M1** | Uses initial conditions to set up equation in $A$ and $B$ |
| $t=0, y=0, x=0 \Rightarrow \frac{dy}{dt} = 0.032\times0 - 0.025\times0 = 0$ | **B1** | Uses initial conditions to find value of $\frac{dy}{dt}$ when $t=0$. Can be implied. |
| $\frac{dy}{dt} = -\frac{A}{200}e^{\frac{-t}{200}} - \frac{13B}{200}e^{\frac{-13t}{200}} = 0 \Rightarrow -\frac{A}{200} - \frac{13B}{200} = 0 \Rightarrow A = -13B$ | **M1** | Differentiates GS, substitutes $t=0$ and sets equal to initial value of $\frac{dy}{dt}$ to form another equation in $A$ and $B$ |
| $y = -\frac{640}{3}e^{\frac{-t}{200}} + \frac{640}{39}e^{\frac{-13t}{200}} + \frac{2560}{13}$ | **A1** | Correct particular solution, accepting awrt 197 |

### Part (d):

| Answer/Working | Mark | Guidance |
|---|---|---|
| As $t \to \infty$, $e^{-kt} \to 0$ for $k > 0$ so $y \to \ldots$ | **M1** | Uses the limit of the exponential terms being zero to find the long term limit of the concentration |
| $y \to \frac{2560}{13} \approx 196$ or $197$, so the rate of administration is sufficient to reach the required level. | **A1ft** | Follow through on their constant term and draws a relevant conclusion |
\begin{enumerate}
  \item A patient is treated by administering an antibiotic intravenously at a constant rate for some time.
\end{enumerate}

Initially there is none of the antibiotic in the patient.\\
At time $t$ minutes after treatment began

\begin{itemize}
  \item the concentration of the antibiotic in the blood of the patient is $x \mathrm { mg } / \mathrm { ml }$
  \item the concentration of the antibiotic in the tissue of the patient is $y \mathrm { mg } / \mathrm { ml }$
\end{itemize}

The concentration of antibiotic in the patient is modelled by the equations

$$\begin{aligned}
& \frac { \mathrm { d } x } { \mathrm {~d} t } = 0.025 y - 0.045 x + 2 \\
& \frac { \mathrm {~d} y } { \mathrm {~d} t } = 0.032 x - 0.025 y
\end{aligned}$$

(a) Show that

$$40000 \frac { \mathrm {~d} ^ { 2 } y } { \mathrm {~d} t ^ { 2 } } + 2800 \frac { \mathrm {~d} y } { \mathrm {~d} t } + 13 y = 2560$$

(b) Determine, according to the model, a general solution for the concentration of the antibiotic in the patient's tissue at time $t$ minutes after treatment began.\\
(c) Hence determine a particular solution for the concentration of the antibiotic in the tissue at time $t$ minutes after treatment began.

To be effective for the patient the concentration of antibiotic in the tissue must eventually reach a level between $185 \mathrm { mg } / \mathrm { ml }$ and $200 \mathrm { mg } / \mathrm { ml }$.\\
(d) Determine whether the rate of administration of the antibiotic is effective for the patient, giving a reason for your answer.

\hfill \mbox{\textit{Edexcel CP2 2023 Q9 [14]}}